The Effect Of Alpha 3 Fatty Acids And Pioglitazone Essay

Modulating effects of omega-3 fatty acids and pioglitazone combination on insulin resistance through toll-like receptor 4 in type 2 diabetes mellitus SALMA MOSSAD ERAKY *, NOHA ABDEL-RAHMAN, LAILA AHMED EISSA. Biochemistry Department, Faculty of Pharmacy, Mansoura University, Egypt, 35516 Correspondence, (salmamossad2012@gmail.com), Tel.: 0020 1098969384. Abstract: Toll-like receptor 4 (TLR-4) plays important roles in innate immunity. Changes in the reduction-oxidation balance of tissues can lead to a pro-inflammatory state and insulin resistance. An action thought to be mediated by TLRs. Omega-3 fatty acids and Peroxisome Proliferator Activated Receptor gamma (PPAR-ÃŽ ³) agonists as pioglitazone are used for decreasing inflammation. The aim of this study is to investigate the anti-diabetic effects of combining omega -3 fatty acid with pioglitazone on type 2 diabetes, and the modulating effects on TLR-4. Type 2 diabetes was induced in male Sprague-Dawley rats by combination of high fat diet and low dose streptozotocin (35 mg/kg). Diabetic rats were treated with omega-3 fatty acids (10% W/W diet), pioglitazone (20 mg/kg), and their combination for 4 weeks. Omega-3 fatty acids and the combination treatment significantly decreased TLR-4 activation. Omega-3 fatty acids, pioglitazone, and their combination significantly decreased TLR-4 mRNA expressi on, hepatic malondialdehyde, total cholesterol and triglycerides levels, compared to diabetic group. 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